業績(論文/総説)

Inhibitory Effect of Kori-tofu Protein on Denervation-Induced Atrogene Expression in Mouse Skeletal Muscle.

Uchida T,  Kohno M, Ito C, Yamano E, Matsuki H, Rahman MD Mizanur, Ulla A,, Suzuki M, Ishiguro T, Nikawa T.

Biological Sciences in Space. 2024. 38:1-7

The reciprocal regulation between mitochondrial-associated membranes and Notch signaling in skeletal muscle atrophy.

Ito Y, Yamagata M, Yamamoto T, Hirasaka K, Nikawa T, Sato T.

Elife. 2023. Dec 15;12:RP89381.

Combinatorial expression of ebony and tan generates body color variation from nymph through adult stages in the cricket, Gryllus bimaculatus.

Inoue S, Watanabe T, Hamaguchi T, Ishimaru Y, Miyawaki K, Nikawa T, Takahashi A, Noji S, Mito T.

PLoS One. 2023. May 18;18(5):e0285934.

Correction to: Suppressive effects of processed aconite root on dexamethasone-induced muscle ring finger protein-1 expression and its active ingredients.

Kondo T, Ishida T, Ye K, Muraguchi M, Tanimura Y, Yoshida M, Ishiuchi K, Abe T, Nikawa T, Hagihara K, Hayashi H, Makino T.

J Nat Med. 2023. Jun;77(3):620.

Daily Dietary Supplementation with Steamed Soybean Improves Muscle Volume and Strength in Healthy People Lacking Exercise.

Kohno M, Ulla A, Taniguchi R, Ohishi A, Hirayama K, Takemura Y, Takao S, Kanazawa Y, Matsumoto Y, Harada M, Fukawa T, Kanayama HO, Uchida T, Suzuki T, Nikawa T.

J Nutr Sci Vitaminol (Tokyo). 2022. 68(6):521-526.

Astaxanthin Exerts Immunomodulatory Effect by Regulating SDH-HIF-1α Axis and Reprogramming Mitochondrial Metabolism in LPS-Stimulated RAW264.7 Cells.

Sun L, Kim S, Mori R, Miyaji N, Nikawa T, Hirasaka K.

Mar Drugs. 2022. Oct 25;20(11):660.

Morin improves dexamethasone-induced muscle atrophy by modulating atrophy-related genes and oxidative stress in female mice.

Ulla A, Osaki K, Rahman MM, Nakao R, Uchida T, Maru I, Mawatari K, Fukawa T, Kanayama HO, Sakakibara I, Hirasaka K, Nikawa T.

Biosci Biotechnol Biochem. 2022. Sep 23;86(10):1448-1458.

Balenine, Imidazole Dipeptide Promotes Skeletal Muscle Regeneration by Regulating Phagocytosis Properties of Immune Cells.

Yang M, Sun L, Kawabata Y, Murayama F, Maegawa T, Nikawa T, Hirasaka K.

Mar Drugs. 2022. May 5;20(5):313.

Additional effects of simultaneous treatment with C14-Cblin and celastrol on the clinorotation-induced rat L6 myotube atrophy.

Kitahata K, Uchida T, Taniguchi R, Kato A, Sugiura K, Sakakibara I, Oarada M, Fukawa T, Junsoo P, Inho C, Nikawa T.

J Med Invest. 2022. 69(1.2):127-134.

All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal.

Adachi Y, Masuda M, Sakakibara I, Uchida T, Niida Y, Mori Y, Kamei Y, Okumura Y, Ohminami H, Ohnishi K, Yamanaka-Okumura H, Nikawa T, Taketani Y.

Life Sci Alliance. 2022. Mar 22;5(7):e202101345.

Suppressive effects of processed aconite root on dexamethasone-induced muscle ring finger protein-1 expression and its active ingredients.

Kondo T, Ishida T, Ye K, Muraguchi M, Tanimura Y, Yoshida M, Ishiuchi K, Abe T, Nikawa T, Hagihara K, Hayashi H, Makino T.

J Nat Med. 2022. Jun;76(3):594-604.

MuRF1 deficiency prevents age-related fat weight gain, possibly through accumulation of PDK4 in skeletal muscle mitochondria in older mice.

Sugiura K, Hirasaka K, Maeda T, Uchida T, Kishimoto K, Oarada M, Labeit S, Ulla A, Sakakibara I, Nakao R, Sairyo K, Nikawa T.

J Orthop Res. 2022. May;40(5):1026-1038.

和文総説

ケトジェニックダイエット摂取に対する骨格筋の応答

中尾 玲子
生化学, Vol.94, No.5, 730-734, 2022年10月.

Dietary Sodium Nitrite Causes Similar Modifications to Splenic Inflammatory Gene Expression as a High-Fat Diet.

Oarada M, Okumura Y, Hirasaka K, Sugiura K, Tachibana N, Tsurusaki Y, Nikawa T.

J Nutr Sci Vitaminol (Tokyo). 2021. 67(6):404-416.

Oral intake of rice overexpressing ubiquitin ligase inhibitory pentapeptide prevents atrophy in denervated skeletal muscle.

Nakao R, Shen W, Shimajiri Y, Kainou K, Sato Y, Ulla A, Ohnishi K, Ninomiya M, Ohno A, Uchida T, Tanaka M, Akama K, Matsui T, Nikawa T.

NPJ Sci Food. 2021. Sep 9;5(1):25.

Polyphenols and Their Effects on Muscle Atrophy and Muscle Health.

Nikawa T, Ulla A, Sakakibara I.

Molecules. 2021. Aug 12;26(16):4887.  

Findings from recent studies by the Japan Aerospace Exploration Agency examining musculoskeletal atrophy in space and on Earth.

Furukawa S, Chatani M, Higashitani A, Higashibata A, Kawano F, Nikawa T, Numaga-Tomita T, Ogura T, Sato F, Sehara-Fujisawa A, Shinohara M, Shimazu T, Takahashi S, Watanabe-Takano H.

NPJ Microgravity. 2021. May 26;7(1):18.

Functional rice with tandemly repeated Cbl-b ubiquitin ligase inhibitory pentapeptide prevents denervation-induced muscle atrophy in vivo.

Akama K, Shimajiri Y, Kainou K, Iwasaki R, Nakao R, Nikawa T, Nishikawa A.

Biosci Biotechnol Biochem. 2021. May 25;85(6):1415-1421.

Morin attenuates dexamethasone-mediated oxidative stress and atrophy in mouse C2C12 skeletal myotubes.

Ulla A, Uchida T, Miki Y, Sugiura K, Higashitani A, Kobayashi T, Ohno A, Nakao R, Hirasaka K, Sakakibara I, Nikawa T.

Arch Biochem Biophys. 2021. Jun 15;704:108873.

Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza.

Ohno A, Maita N, Tabata T, Nagano H, Arita K, Ariyoshi M, Uchida T, Nakao R, Ulla A, Sugiura K, Kishimoto K, Teshima-Kondo S, Okumura Y, Nikawa T.

Life Sci Alliance. 2021. Apr 5;4(6):e202000849.

Astaxanthin Prevents Atrophy in Slow Muscle Fibers by Inhibiting Mitochondrial Reactive Oxygen Species via a Mitochondria-Mediated Apoptosis Pathway.

Sun L, Miyaji N, Yang M, Mills EM, Taniyama S, Uchida T, Nikawa T, Li J, Shi J, Tachibana K, Hirasaka K.

Nutrients. 2021. Jan 26;13(2):379.

Chocolate as a food matrix reduces the bioavailability of galloylated catechins from green tea in healthy women.

Mukai R, Fukuda T, Ohnishi A, Nikawa T, Furusawa M, Terao J.

Food Funct. 2021. Jan 7;12(1):408-416.

Overexpressed osteoactivin reduced osteoclastic callus resorption during distraction osteogenesis in mice.

Yukata K, Nikawa T, Takahashi M, Yasui N.

J Pediatr Orthop B. 2021. Sep 1;30(5):500-506.

A Diet Including Red Bell Pepper Juice and Soy Protein Suppress Physiological Markers of Muscle Atrophy in Mice.

Tachibana N, Fukao M, Irie T, Irisawa Y, Shirono H, Oarada M, Nikawa T, Fukaya T.

J Nutr Sci Vitaminol (Tokyo). 2020. 66(5):449-455.

Reduction of stearoyl-CoA desaturase (SCD) contributes muscle atrophy through the excess endoplasmic reticulum stress in chronic kidney disease.

Niida Y, Masuda M, Adachi Y, Yoshizawa A, Ohminami H, Mori Y, Ohnishi K, Yamanaka-Okumura H, Uchida T, Nikawa T, Yamamoto H, Miyazaki M, Taketani Y.

J Clin Biochem Nutr. 2020. Sep;67(2):179-187.

Ubiquitin ligase Cbl-b and inhibitory Cblin peptides.

Nikawa T, Ishidoh K.

Biochim Biophys Acta Proteins Proteom. 2020. Nov;1868(11):140495.

Ultra-high-purity iron is a novel and very compatible biomaterial.

Khan L, Sato K, Okuyama S, Kobayashi T, Ohashi K, Hirasaka K, Nikawa T, Takada K, Higashitani A, Abiko K.

J Mech Behav Biomed Mater. 2020. Jun;106:103744. 

Ketogenic diet induces skeletal muscle atrophy via reducing muscle protein synthesis and possibly activating proteolysis in mice.

Nakao R, Abe T, Yamamoto S and Oishi K.

Scientific Reports, 2019.Vol.9, No.1,

和文総説

筋ミトコンドリアによる重力感知,
内田 貴之, 二川 健, 中尾 玲子 

生体の科学, Vol.70, No.4, 301-305, 2019年5月

Morin suppresses cachexia-induced muscle wasting by binding to ribosomal protein S10 in carcinoma cells.

Yoshimura T, Saitoh K, Sun L, Wang Y, Taniyama S, Yamaguchi K, Uchida T, Ohkubo T, Higashitani A, Nikawa T, Tachibana K, Hirasaka K.

Biochem Biophys Res Commun. 2018. Dec 2;506(4):773-779.

Dietary supplementation with alkylresorcinols prevents muscle atrophy through a shift of energy supply.

Hiramoto S, Yahata N, Saitoh K, Yoshimura T, Wang Y, Taniyama S, Nikawa T, Tachibana K, Hirasaka K.

J Nutr Biochem. 2018. Nov;61:147-154.

VEGF pathway-targeting drugs induce evasive adaptation by activation of neuropilin-1/cMet in colon cancer cells.

Tomida C, Yamagishi N, Nagano H, Uchida T, Ohno A, Hirasaka K, Nikawa T, Teshima-Kondo S.

Int J Oncol. 2018. Apr;52(4):1350-1362.

Reactive oxygen species upregulate expression of muscle atrophy-associated ubiquitin ligase Cbl-b in rat L6 skeletal muscle cells.

Uchida T, Sakashita Y, Kitahata K, Yamashita Y, Tomida C, Kimori Y, Komatsu A, Hirasaka K, Ohno A, Nakao R, Higashitani A, Higashibata A, Ishioka N, Shimazu T, Kobayashi T, Okumura Y, Choi I, Oarada M, Mills EM, Teshima-Kondo S, Takeda S, Tanaka E, Tanaka K, Sokabe M, Nikawa T.

Am J Physiol Cell Physiol. 2018. Jun 1;314(6):C721-C731.

Distinct Gene Expression Profile Distinguishes Increased Metabolic Activity in Spontaneously Hyperactive Rats While Sedentary from That Induced by Exercise.

Manami Abe, Yuki Matsuo, Akiko Harada, Takayuki Uchida, Kanako Kitahata, Chisato Tomida, Katsuya Hirasaka, Shigetada Kondo, Nagakatsu Harada, Yutaka Nakaya, Hiroshi Sakaue, Reiko　Nakao and Takeshi Nikawa
Advances in Biological Chemistry, 2018. Vol.8, No.01, 1-14.

和文総説

サルコペニアとメカニカルストレス,

中尾 玲子, 内田 貴之, 二川 健
診断と治療, Vol.106, No.6, 701-704, 2018年6月.

Co-Administration of Myostatin-Targeting siRNA and ActRIIB-Fc Fusion Protein Increases Masseter Muscle Mass and Fiber Size.

Bayarsaikhan O, Kawai N, Mori H, Kinouchi N, Nikawa T, Tanaka E.

J Nutr Sci Vitaminol (Tokyo). 2017.63(4):244-248.

Regorafenib induces adaptive resistance of colorectal cancer cells via inhibition of vascular endothelial growth factor receptor.

Tomida C, Nagano H, Yamagishi N, Uchida T, Ohno A, Hirasaka K, Nikawa T, Teshima-Kondo S.

J Med Invest. 2017.64(3.4):262-265.

Antiangiogenic agent sunitinib induces epithelial to mesenchymal transition and accelerates motility of colorectal cancer cells.

Tomida C, Yamagishi N, Nagano H, Uchida T, Ohno A, Hirasaka K, Nikawa T, Teshima-Kondo S.

J Med Invest. 2017.64(3.4):250-254.

Altered KYN/TRP, Gln/Glu, and Met/methionine sulfoxide ratios in the blood plasma of medication-free patients with major depressive disorder.

Umehara H, Numata S, Watanabe SY, Hatakeyama Y, Kinoshita M, Tomioka Y, Nakahara K, Nikawa T, Ohmori T.

Sci Rep. 2017.Jul 7;7(1):4855.

Nutritional counseling regulates interdialytic weight gain and blood pressure in outpatients receiving maintenance hemodialysis.

Sakai A, Hamada H, Hara K, Mori K, Uchida T, Mizuguchi T, Minaguchi J, Shima K, Kawashima S, Hamada Y, Nikawa T.

J Med Invest. 2017.64(1.2):129-135.

Involvement of Cbl-b-mediated macrophage inactivation in insulin resistance.

Abe T, Hirasaka K, Nikawa T.

World J Diabetes. 2017.Mar 15;8(3):97-103.

Ketogenic diet induces expression of the muscle circadian gene Slc25a25 via neural pathway that might be involved in muscle thermogenesis.

Nakao R, Shimba S, and Oishi K.

Scientific Reports, 2017. Vol.7, No.1, 2885.

Determination of reference genes that are independent of feeding rhythms for circadian studies of mouse metabolic tissues.,
Nakao R, Okauchi H, Hashimoto C, Wada N, and Oishi K.
Molecular Genetics and Metabolism, 2017.Vol.121, No.2, 190-197

Development and performance evaluation of a three-dimensional clinostat synchronized heavy-ion irradiation system.

Ikeda H, Souda H, Puspitasari A, Held KD, Hidema J, Nikawa T, Yoshida Y, Kanai T, Takahashi A.

Life Sci Space Res (Amst). 2017.Feb;12:51-60.

Metabolic Suppression by 3-Iodothyronamine Induced Muscle Cell Atrophy via Activation of FoxO-Proteasome Signaling and Downregulation of Akt1-S6K Signaling.

Ju H, Kim T, Chung CM, Park J, Nikawa T, Park K, Choi I.

Biol Pharm Bull. 2017.May 1;40(5):576-582.

Modulation of cutaneous extracellular collagen contraction by phosphorylation status of p130Cas.

Takeya M, Okumura Y, Nikawa T.

J Physiol Sci. 2017.Sep;67(5):613-622.

和文総説

The skeletal muscle circadian clock: current insights,

Nakao R, Nikawa T and Oishi K
ChronoPhysiology and Therapy, 2017.Vol.7, 47-57, Nov.

和文総説

[Update on recent progress in vitamin D research. Vitamin D and muscle tissues.].

Kaneko I, Miyamoto KI, Nikawa T.

Clin Calcium. 2017.27(11):1571-1578.

和文総説

[Plasticity of skeletal muscle against unloading stress.]

Kishimoto H, Uchida T, Kitahata K, Nikawa T.

Clin Calcium. 2017.27(3):351-356.

和文総説

[Impacts of physical exercise on remodeling and hypertrophy of skeletal muscle.].

Sakashita Y, Uchida T, Nikawa T.

Clin Calcium. 2017.27(1):79-85.